Validity of a Spanish Version of the Leicester Cough Questionnaire in Children With Cystic Fibrosis

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• 作者：Tamara del Corral^a ; Janaí ; na Percegona^b ; Nú ; ria Ló ; pez^c ; Andrea Valiente^c ; Marí ; a Garriga^d ; Melisa Seborga^a ; Jordi Vilaró ; ^e ; ^{jordivc@blanquerna.url.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cystic fibrosis ; Cough ; Cough questionnaire and health related quality of life
• 刊名：Archivos de Bronconeumología (English Edition)
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：52
• 期：2
• 页码：63-69
• 全文大小：650 K

文摘

Cystic fibrosis (CF) patients present chronic cough as one of the main symptoms, which has an important effect on quality of life and social relations. Our goal was to validate the Spanish version of the Leicester Cough Questionnaire (LCQ) in a group of children and teenagers with CF.

Methods

After adapting to Spanish by standardized translation and retro-translation methodology, a sample of 58 stable CF patients from 7 to 18 years were recruited from three CF specialized centers in Spain. The questionnaire was administered twice; the second administration (LCQ₂) was performed between 2 and 4 weeks later than the first one (LCQ₁), in order to analyze the reliability and validity of the Spanish version. To correlate results with health related quality of life (HRQoL) we used the Cystic Fibrosis Questionnaire-Revised (CFQ-R).

Results

Population was composed by 62% male, age 11.7 ± 3.1 years and body mass index (BMI) 19 ± 3 kg/m². Total scores from LCQ were: LCQ1 19 (17.75–21) vs LCQ2 19 (16–21) (P=.199). Cronbach's Alpha coefficient was 0.83 for the LCQ_total and for each specific domain was: 0.82 LCQ_physical; 0.74 LCQ_{psychological} and 0.62 LCQ_social. Intraclass correlation coefficient was: 0.69 LCQ_physical; 0.59 LCQ_{psychological}; 0.45 LCQ_social and 0.71 LCQ_total (good reliability). Relations with CFQ-R showed moderated and significant results: LCQ_totalr = 0.51 (P<.001) and respiratory symptoms domain r=0.67 (P<.05).

Conclusion

The Spanish version of the Leicester Cough Questionnaire is reliable and valid for children and adolescents with CF and it has good relations with health related quality of life in this population.