Melamine and cyanuric acid co-exposure causes renal dysfunction and structural damage via MAPKs and mitochondrial signaling
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- 作者：In-Chul Leea ; b ; Je-Won Koa ; Sung-Hyeuk Parka ; In-Sik Shina ; Changjong Moona ; Sung-Ho Kima ; Yun-Bae Kimc ; Jong-Choon Kima ; toxkim@jnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melamine ; Cyanuric acid ; Nephrotoxicity ; Mitogen-activated protein kinases ; Apoptosis
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：254-262
- 全文大小：1841 K
文摘
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M + CA caused functional and histopathological alteration in the kidneys.
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M + CA increased lipid peroxidation and decreased antioxidant enzyme activities in the kidneys.
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M + CA induced renal tubular cell apoptotic changes in the kidneys.
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M + CA caused phosphorylation of mitogen-activated protein kinases (MAPKs).
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M + CA increased Bax and decreased Bcl2 levels with caspase-3 activation in the kidneys.