Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression
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- 作者：Colm G. Connollya ; colm.connolly@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Tiffany C. Hoa ; b ; Eva Henje Bloma ; c ; Kaja Z. LeWinna ; Matthew D. Saccheta ; b ; d ; Olga Tymofiyevae ; Alan N. Simmonsf ; g ; Tony T. Yanga
- 关键词：Adolescent major depression ; Resting-state ; Amygdala ; Dorsolateral prefrontal cortex ; Ventromedial prefrontal cortex
- 刊名：Journal of Affective Disorders
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：207
- 期：Complete
- 页码：86-94
- 全文大小：496 K
文摘
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At baseline, depressed adolescents exhibited reduced connectivity between amygdala and dorsolateral prefrontal cortex.
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At baseline, depressed adolescents showed reduced amygdala connectivity with ventromedial prefrontal cortex.
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More positive baseline amygdala connectivity with insula was associated with reduced symptom severity three months later.
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Indictors of depression absence/presence are distinct from those associated with change in depression symptoms over time.