- 作者：V. Bykov ; a ; Viatcheslav.Bykov@kit.edu" class="auth_mail" title="E-mail the corresponding author ; vladimir@bgu.ac.il" class="auth_mail" title="E-mail the corresponding author ; V. Gol&rsquo ; dshteinb
- 关键词：Biochemical reactions ; Apoptosis ; Model reduction ; GQL
- 刊名：Mathematical Biosciences
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：275
- 期：Complete
- 页码：39-50
- 全文大小：1775 K
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A mathematical method for reducing biochemical kinetics is presented.
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The method is applied to reduce the FAS-induced apoptotic intracellular-signaling subsystem (of 28 dimensions).
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Nine linear integrals (conserved relations) of the original model are reported and used to reduce the system dimension without any loss of the accuracy.
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Four additional relations allow us to further reduce the system dimension. Three of them represent a combination of fast synchronizing reactions regarded as relatively fast and relaxed and one presents an additional non-linear system integral.
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The reduced model together with numerical simulations results of the comparison between detailed and reduced models are reported.
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The numerical results show the high accuracy of the reduced model.