Bone mineral properties in growing Col1a2+/G610C mice, an animal model of osteogenesis imperfecta
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- 作者：Marco Mascia ; mam2147@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Min Wangb ; 1 ; 19650877@qq.com" class="auth_mail" title="E-mail the corresponding author ; Laurianne Imbertb ; ImbertL@HSS.edu" class="auth_mail" title="E-mail the corresponding author ; Aileen M. Barnesc ; Barnesai@mail.Nih.gov" class="auth_mail" title="E-mail the corresponding author ; Lyudmila Spevakb ; SpevakM@HSS.edu" class="auth_mail" title="E-mail the corresponding author ; Lyudmila Lukashovab ; Lukashoval@HSS.edu" class="auth_mail" title="E-mail the corresponding author ; Yihe Huangd ; Yihehuang@email.gwu.edu" class="auth_mail" title="E-mail the corresponding author ; Yan Mad ; yanma@email.gwu.edu" class="auth_mail" title="E-mail the corresponding author ; Joan C. Marinic ; oidoc@helix.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Christina M. Jacobsene ; f ; Christina.jacobsen@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Matthew L. Warmang ; Matthew.Warman@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Adele L. Boskeya ; b ; Boskeya@HSS.edu" class="auth_mail" title="E-mail the corresponding author ; ABoskey@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteogenesis imperfecta ; FTIRI ; Micro-computed tomography ; Old order Amish mice ; G610C mutation
- 刊名：Bone
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：87
- 期：Complete
- 页码：120-129
- 全文大小：1342 K
文摘
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Composition and morphology of mouse bones with a G610C collagen mutation were compared to WT.
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At 10 d few changes in micro-CT or FTIRI measures in similar bone types in G610C mutants vs. WT.
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At 2 mo G610C mutant cortical and trabecular bones were thinner with higher mineral content.
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At 2 mo G610C mutant cortical and trabecular bones had altered composition.
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An Lrp5 high-bone-mass allele partly rescued the compositional phenotype in 3 mo-old femurs.