Both MgSO4 and diltiazem reduce blood loss in FESS when added to propofol-based anesthesia, MgSO4 being significantly more effective in producing a cleaner surgical field.
At the dosage used, neither MgSO4 nor diltiazem produced any significant change in hemodynamics compared with saline control.
The improvement may be attributed to stabilization of microfluctuations in blood pressure by these agents.