Altered gene expression of the innate immune, neuroendocrine, and nuclear factor-kappa B (NF-κB) systems is associated with posttraumatic stress disorder in military personnel
详细信息 查看全文
- 作者：Pedro Guardadoa ; Anlys Oliveraa ; Heather L. Ruscha ; b ; Michael Royc ; Christiana Martina ; Natasha Lejbmana ; Hwyunhwa Leed ; Jessica M. Gilla ; gillj@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gene expression ; Innate immune ; Neuroendocrine ; NF-κB ; PTSD ; Trauma
- 刊名：Journal of Anxiety Disorders
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：9-20
- 全文大小：1547 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
A total of 203 genes were differentially expressed in military personnel with PTSD.
- class="label">•
Findings were independent of depression severity, history of TBI, and meditation use.
- class="label">•
IPA identified dysregulated innate immune, glucocorticoid receptor, and NF-κB pathways.
- class="label">•
The PTSD group showed upregulation in pro-inflammatory cytokine genes.
- class="label">•
Findings suggest that inflammation may be a significant factor in PTSD pathogenesis.