Reduced serologic sensitivity to influenza A virus illness among inactivated influenza vaccinees

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• 作者：Mark G. Thompson^a ; ^{isq8@cdc.gov" class="auth_mail" title="E-mail the corresponding author} ; Manjusha J. Gaglani^b ; Allison L. Naleway^c ; Samuel H. Dowell^a ; Sarah Spencer^a ; Sarah Ball^d ; Min Levine^a ; Alicia Fry^a
• 关键词：Influenza ; Hemagglutinin inhibition ; Seroconversion ; Antibody ; Influenza vaccine ; Immunogenicity ; Vaccine failure
• 刊名：Vaccine
• 出版年：2016
• 出版时间：24 June 2016
• 年：2016
• 卷：34
• 期：30
• 页码：3443-3446
• 全文大小：370 K

文摘

We compared ≥4-fold increases in antibody titers by hemagglutination inhibition assay to RT-PCR results among 42 adults with PCR-confirmed influenza A virus illnesses. Serologic sensitivity was higher among unvaccinated (69%, 95% confidence interval [CI] = 48–90%) than vaccinated healthcare personnel (38%, 95% CI = 29–46%) in a 2010–11 prospective cohort.