class="boldFont">Background: New strategies that promote clearance of excess cholesterol by reverse cholesterol transport (RCT) are needed.
class="boldFont">Results: SOF promotion of hepatic CE uptake, metabolism and secretion as bile acids in vitro and in vivo was investigated.
class="boldFont">Conclusion: Both in vitro and in vivo, CERM-CE is metabolized by hepatocytes to bile acids and secreted.
class="boldFont">Significance: The SOF product CERM delivers cholesterol to the liver, supporting it as a therapeutic strategy to promote RCT.