Gene expression test for the non-invasive diagnosis of bladder cancer: A prospective, blinded, international and multicenter validation study
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- 作者：Maria J. Ribala ; 1 ; mjribal@clinic.ub.es" class="auth_mail" title="E-mail the corresponding author ; Lourdes Menguala ; 1 ; lmengual@clinic.ub.es" class="auth_mail" title="E-mail the corresponding author ; Juan J. Lozanob ; juanjo.lozano@Ciberehd.org" class="auth_mail" title="E-mail the corresponding author ; Mercedes Ingelmo-Torresa ; INGELMO@clinic.ub.es" class="auth_mail" title="E-mail the corresponding author ; Joan Palouc ; jpalou@fundacio-puigvert.es" class="auth_mail" title="E-mail the corresponding author ; Oscar Rodrí ; guez-Fabac ; orodriguez@fundacio-puigvert.es" class="auth_mail" title="E-mail the corresponding author ; Johannes A. Witjesd ; Fred.Witjes@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author ; Antoine G. Van der Heijdend ; Toine.vanderHeijden@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author ; Rafael Medinae ; rantonio.medina.sspa@juntadeandalucia.es" class="auth_mail" title="E-mail the corresponding author ; Jose M. Condee ; jose.conde.sspa@juntadeandalucia.es" class="auth_mail" title="E-mail the corresponding author ; Michael Marbergerf ; michael.marberger@A1.net" class="auth_mail" title="E-mail the corresponding author ; Joerg Schmidbauerf ; joerg.schmidbauer@meduniwien.ac.at" class="auth_mail" title="E-mail the corresponding author ; Pedro L. Ferná ; ndezg ; PLFERNAN@clinic.ub.es" class="auth_mail" title="E-mail the corresponding author ; Antonio Alcaraza ; ALCARAZ@clinic.ub.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bladder cancer ; Biomarkers ; Gene expression ; Molecular test ; Non-invasive diagnosis ; Sensitivity and specificity ; Urine
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：131-138
- 全文大小：804 K
文摘
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External validation of our four urine tests for bladder cancer (BC) diagnosis.
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The four tests achieve the accuracy of the current gold standard of BC diagnosis.
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These tests are non-invasive, non-observer dependent and non-labour-intensive.
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The tests have higher sensitivity than cytology while maintaining its specificity.
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Gene expression urine tests could be used in clinical practice for BC detection.