Monitoring As and Hg variation in An-Gong-Niu-Huang Wan (AGNH) intermediates in a pilot scale blending process using laser-induced breakdown spectroscopy
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- 作者：Xiaona Liu ; Qun Ma ; Shanshan Liu ; Xinyuan Shi ; Qiao Zhang ; Zhisheng Wu ; wzs@bucm.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yanjiang Qiao ; yjqiao@263.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：CMM ; Chinese material medica ; LIBS ; laser-induced breakdown spectroscopy ; ICP-OES ; inductively coupled plasma optical emission spectrometer ; PAT ; process analytical technology ; HPLC ; high-pressure liquid chromatography ; APOI ; active pharmaceutical organic ingredient ; AGNH ; An-Gong-Niu-Huang Wan ; As ; arsenic ; Hg ; mercury ; RICR ; relative intensity changing rate ; MWSD ; moving window standard deviation ; RCCR ; relative concentration changing rate
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2015
- 出版时间：5 December 2015
- 年：2015
- 卷：151
- 期：Complete
- 页码：547-552
- 全文大小：1618 K
文摘
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As and Hg emission lines could be determined by LIBS in complex matrix effects.
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Blending end-point was determined by RICR, MWSD and RCCR algorithms.
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LIBS result was consistent with ICP-OES at blending end-point determination.
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LIBS is a viable technique for monitoring the blending process of mineral medicines.