CD62-mediated activation of platelets in cerebral white matter lesions in patients with cognitive decline
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- 作者：Nagato Kuriyamaa ; b ; nkuriyam@koto.kpu-m.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Toshiki Mizunob ; Hiromi Yasuikeb ; Hiroyuki Matsunoc ; Eri Kawashitac ; Aiko Tamurab ; Etsuko Ozakia ; Daisuke Matsuia ; Isao Watanabea ; Teruhide Koyamaa ; Fumitaro Miyatania ; Masaki Kondob ; Takahiko Tokudab ; Youichi Ohshimab ; Manabu Muranishib ; Kentaro Akazawad ; Akihiro Takadae ; Kazuo Takedae ; Sanae Matsumotoe ; Shigeto Mizunof ; Kei Yamadad ; Masanori Nakagawab ; Yoshiyuki Watanabea
- 关键词：Deep white matter lesion (DWML) ; Cognitive decline ; Platelet activation ; CD62P
- 刊名：Archives of Gerontology and Geriatrics
- 出版年：2016
- 出版时间：January-February 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：118-124
- 全文大小：438 K
文摘
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Expressions of CD62P on circulating platelets were observed in patients with increasing grades of cerebral deep white matter lesions (DWMLs).
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The multivariate analysis for higher CD62P values showed that the odds ratio in the high-grade DWMLs group was 3.03 compared with the low-grade DWMLs group.
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CD62P levels could be useful as an additional clinical marker for the early detection of DWML-related cognitive decline.