Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease
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- 作者：Tatiana Melnikovaa ; tmelnik1@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; DaMin Parka ; dpark39@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Lauren Beckera ; lnb785@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Deidre Leea ; lee.deidre@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Eugenia Choa ; eugeniacho87@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Nuzhat Sayyidaa ; naz0789@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jing Tianb ; jtian4@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Karen Bandeen-Rocheb ; kbandeen@jhsph.edu" class="auth_mail" title="E-mail the corresponding author ; David R. Borcheltc ; drb1@ufl.edu" class="auth_mail" title="E-mail the corresponding author ; Alena V. Savonenkoa ; asavone1@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：APP ; amyloid precursor protein ; APPsi ; APP with Swedish and Indiana mutations ; sAPP ; soluble N-terminal fragment of APP ; CaMKIIα ; calcium-calmodulin-dependent kinase II α ; CTF ; C-terminal fragment of APP ; DG ; dental gyrus of the hippocampus ; FL-APP ; full length APP ; PPI ; prepulse inhibition of acoustic startle reflex ; PrP ; Prion protein ; SDS ; sodium dodecyl sulfate ; tTa ; tetracycline transactivator
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：171-185
- 全文大小：2856 K
文摘
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APP models utilizing Prion promoter show higher APP levels in females than in males
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The CaMKII-tTa:APP models lack sex-related differences in APP/Aβ levels
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In this setting, females show enhanced atrophy of dentate gyrus of the hippocampus
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Females also reveal earlier onset of deficits in conditioned freezing/hyperactivity
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These sex dimorphisms might reflect a higher sensitivity of females to APP/Aβ