Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury
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- 作者：Leyan Xua ; lxu9@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Jiwon Ryua ; jryu4@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Judy V. Nguyenb ; judy.v.nguyen@gmail.com" class="auth_mail" title="E-mail the corresponding author ; John Arenaa ; jarena2@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Elizabeth Rhaa ; lizrha@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Pamela Vranisa ; pvranis1@jhu.edu" class="auth_mail" title="E-mail the corresponding author ; Devon Hitta ; dhitt@sas.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Nicholas Marsh-Armstrongb ; c ; marsh-armstrong@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Vassilis E. Koliatsosa ; d ; e ; koliat@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; CTE ; chronic traumatic encephalopathy ; DAB ; 3 ; 3&prime ; -diaminobenzidine ; FTD ; frontotemporal degeneration ; IA ; impact acceleration ; IHC ; immunohistochemistry ; mTBI ; mild traumatic brain injury ; NFL ; National Football League ; NSS ; neurological severity score ; RGCs ; retinal ganglion cells ; TAI ; traumatic axonal injury
- 刊名：Experimental Neurology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：273
- 期：Complete
- 页码：168-176
- 全文大小：2461 K
文摘
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Single and repetitive mild TBI substantially increased the number of tau pS422 (+) RGCs in transgenic P301S tau mice
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TBI burden (number of hits) was a significant factor determining tau pS422 (+) accumulation in RGCs
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Repetitive mild TBI also increased tau pS422 (+) RGCs in transgenic mice carrying all 6 human tau isoforms with no mouse tau
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Brain regions featured by severe traumatic axonal injury may be more susceptible to TBI-induced acceleration of tauopathy