Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
详细信息 查看全文
- 作者：Joanne S. Allarda ; d ; joanne.allard@howard.edu" class="auth_mail" title="E-mail the corresponding author ; Evelyn J. Perezb ; Koji Fukuic ; d ; Priscilla Carpentera ; Donald K. Ingrame ; Rafael de Cabod ; decabora@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：HF ; high fat ; HFM ; high fat plus metformin ; BDNF ; brain derived neurotrophic factor ; NGF ; nerve growth factor ; NT3 ; neurotrophin 3 ; Nrf2 ; nuclear factor erythroid 2-related factor
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：1-9
- 全文大小：1377 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
A mouse model was used to determine the effect of high fat diet and metformin treatment on cognition, brain neurotrophic factor expression and Nrf2 expression.
- class="label">•
Transcripts of three major neurotrophic factors were decreased in brains of metformin treated mice.
- class="label">•
Brain protein and mRNA levels of the antioxidant regulatory factor Nrf2 were decreased by metformin treatment.
- class="label">•
Long-term high dose metformin use may create disadvantageous biochemical conditions in the brain.