Molecular biomarkers of thrombosis in myeloproliferative neoplasms
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- 作者：Tiziano Barbuia ; tbarbui@asst-pg23.it" class="auth_mail" title="E-mail the corresponding author ; Anna Falangab
- 关键词：Myeloproliferative neoplasms ; Driver genes ; JAK2 mutations ; Thrombosis
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：140
- 期：supp_S1
- 页码：S71-S75
- 全文大小：462 K
文摘
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Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are myeloproliferative neoplasms (MPN) and are characterized by mutually exclusive JAK2, CALR and MPL mutations
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Thrombotic events are very frequent and represent the main cause of morbidity and mortality in patients with MPN
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JAK2V617F mutation is the major contributory factor for the pathogenesis of thrombosis in MPN
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Pathogenesis of blood clotting activation in these diseases is multifactorial, and involves various abnormalities of hemostatic cells