The E-box-like sterol regulatory element mediates the insulin-stimulated expression of hepatic clusterin
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- 作者：Gyun-Sik Oha ; b ; 1 ; Gukhan Kima ; 1 ; 2 ; Jin Yoona ; b ; Geun Hyang Kima ; 3 ; Seung-Whan Kima ; b ; swkim7@amc.seoul.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Clusterin ; Apolipoprotein J ; Insulin ; Sterol regulatory element binding protein-1c ; Non-canonical E-box
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：25 September 2015
- 年：2015
- 卷：465
- 期：3
- 页码：501-506
- 全文大小：835 K
文摘
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This is the first report of metabolic hormone-regulated clusterin expression.
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Clusterin expression is increased by insulin signaling in hepatocytes.
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SREBP-1c mediates the transcriptional activation of clusterin by insulin.
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The insulin-stimulated activation process is mediated through a non-canonical E-box.