Cited2 participates in cardiomyocyte apoptosis and maternal diabetes-induced congenital heart abnormality
详细信息 查看全文
- 作者：Dongmei Sua ; 1 ; Jun-Xian Songb ; 1 ; Qianqian Gaoc ; Lina Guana ; Qian Lia ; Cuige Shia ; Xu Maa ; jswkysgc@126.com" class="auth_mail" title="E-mail the corresponding author ; genetic88@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cardiomyocyte apoptosis ; Heart ; Maternal diabetes ; Cited2 ; High glucose
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：479
- 期：4
- 页码：887-892
- 全文大小：1115 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
Maternal and fetal pregnancy outcome in a rat model of diabetic pregnancy.
- class="label">•
Abnormal cardiomyocyte apoptosis participated in ventricular wall thinness.
- class="label">•
The expression of CITED2 decreased in HG-induced apoptosis in cardiomyocytes in vitro and in vivo.
- class="label">•
Over-expression of CITED2 suppressed cardiomyocytes apoptosis induced by high glucose.
- class="label">•
CITED2 mutation partly inhibited the capacity of CITED2 to suppress apoptosis induced by HG in cardiomyocytes.