Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

详细信息查看全文

作者：Daniel Cacabelos^a ; ¹ ; ^{dcacabelos@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Victò ; ria Ayala^a ; ¹ ; ^{victoria.ayala@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Ana Belé ; n Granado-Serrano^a ; ¹ ; ^{anabgs@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Mariona Jové ; ^a ; ¹ ; ^{mariona.jove@udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Pascual Torres^a ; ^{pascual.tc92@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Jordi Boada^a ; ^{jboada@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Rosanna Cabré ; ^a ; ^{rosanna.cabre@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Omar Ramí ; rez-Nú ; ñ ; ez^a ; ^{omar.ramirez78@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Hugo Gonzalo^a ; ^{hugonzalo@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Aranzazu Soler-Cantero^b ; ^{asocan@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; José ; Carlos Enrique Serrano^a ; ^{jceserrano@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Maria Josep Bellmunt^a ; ^{mjosep.bellmunt@cmb.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Marí ; a Paz Romero^b ; ^{maripaz@tecal.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Marí ; a José ; Motilva^b ; ^{motilva@tecal.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Takashi Nonaka^c ; ^{nonaka-tk@igakuken.or.jp" class="auth_mail" title="E-mail the corresponding author} ; Masato Hasegawa^b ; ^{hasegawa-ms@igakuken.or.jp" class="auth_mail" title="E-mail the corresponding author} ; Isidre Ferrer^d ; ^e ; ^{8082ifa@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Reinald Pamplona^a ; ^{reinald.pamplona@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author} ; Manuel Portero-Otí ; n^a ; ^{manuel.portero@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author}
关键词：Motor neuron ; Lipidomic ; Oxidative stress ; TDP-43 ; Polyunsaturated fatty acids ; Mitochondria
刊名：Neurobiology of Disease
出版年：2016
出版时间：April 2016
年：2016
卷：88
期：Complete
页码：148-160
全文大小：2487 K

文摘

class="label">•: Specific enzymes for DHA synthesis are altered in ALS.
class="label">•: ALS is associated with changes in DHA-dependent synaptic proteins drebrin and syntaxin
class="label">•: Chronic excitotoxicity changes nervous tissue lipidome profile compatible with increased DHA amount
class="label">•: DHA synthesis is upregulated by oxidative stress at short term in cell culture
class="label">•: Drebrin is depleted after TDP-43 aggregation and oxidative stress

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700