Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice
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- 作者：V. Martí ; nez-Cisueloa ; vmcisuelo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; J. Gó ; mezb ; jose.gomez@universidadeuropea.es" class="auth_mail" title="E-mail the corresponding author ; I. Garcí ; a-Juncedac ; soyisa@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; A. Naudí ; d ; alba.naudi@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; R. Cabré ; d ; rosanna.cabre@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; N. Mota-Martorelld ; natalia.mota@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; M. Ló ; pez-Torresa ; mltorres@bio.ucm.es" class="auth_mail" title="E-mail the corresponding author ; M. Gonzá ; lez-Sá ; nchezc ; mgs@bio.ucm.es" class="auth_mail" title="E-mail the corresponding author ; R. Pamplonad ; reinald.pamplona@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; G. Barjaa ; gbarja@bio.ucm.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIF ; apoptosis-inducing factor ; CEL ; carboxyethyl-lysine ; CML ; carboxymethyl-lysine ; DBI ; Double Bond Index ; FRL ; % free radical leak ; GSA ; glutamic semialdehyde ; MDAL ; malondialdehyde-lysine ; mitROSp ; mitochondrial ROS production ; mtDNA ; mitochondrial DNA ; mTOR ; mammalian target of rapamycin ; 8-oxodG ; 8-oxo-7 ; 8-dihydro-2&prime ; deoxyguanosine ; PI ; Peroxidizability Index ; RAPTOR ; regulatory-associated protein of m-TOR ; ROS ; reactive oxygen species ; RCR ; respiratory control ratio ; 2-SC ; succinyl-c
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：130-138
- 全文大小：761 K
文摘
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Rapamycin abolishes age-related increases in mitochondrial ROS production and leak at complex I.
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Rapamycin abolishes age-related increases of mtDNA fragments inside nuclear DNA.
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Rapamycin abolishes increases in mitochondrial protein lipoxidation with age.
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Rapamycin increases autophagy and partially abolishes lipofuscin accumulation with age.