Vitiligo: How do oxidative stress-induced autoantigens trigger autoimmunity?
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- 作者：Heng Xiea ; 1 ; xhlion0822@126.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Fubo Zhoua ; 1 ; myzhoufubo@126.com" class="auth_mail" title="E-mail the corresponding author ; Ling Liua ; vanilla@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Guannan Zhua ; rainchu77@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Qiang Lia ; qiangli@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Chunying Lia ; lichying@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Tianwen Gaoa ; gaotw@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ROS ; reactive oxygen species ; UV ; ultraviolet ; DNA ; deoxyribonucleic acid ; Nrf2 ; nuclear factor E2-related factor 2 ; ARE ; antioxidant response element ; HO-1 ; heme oxygenase-1 ; ER ; endoplasmic reticulum ; 8-OHdG ; 8-hydroxy-2&prime ; -deoxyguanosine ; APE1 ; apurinic/apyrimidinic endonuclease 1 ; UPR ; unfolded protein response ; MART-1 ; melanoma antigen recognized by T cells-1 ; ATP ; adenosine triphosphate ; LCs ; Langerhans cells ; DCs ; dendritic cells ; CRT ; calreticulin ; MHC ; major histocompatibility compl
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：81
- 期：1
- 页码：3-9
- 全文大小：1726 K
文摘
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The panorama of the entire procedure in vitiligo (the consecutive occurrences of oxidative stress, damaged melanocytes, autoantigens, autoimmunity and melanocyte destruction) is specifically displayed based on published studies
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The comprehensive causes of the overproduction of reactive oxygen species are summarized.
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The damage to melanocytes due to oxidative stress and the production of subsequent autoantigens is illuminated in detail.
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The specific mechanisms of how autoantigens trigger autoimmunity in vitiligo is demonstrated.