Association between FKBP5 and CRHR1 genes with suicidal behavior: A systematic review
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- 作者：Eduardo De la Cruz-Canoa ; b ; eduardocano239@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACTH ; adrenocorticotropic hormone ; cAMP ; cyclic adenosine monophosphate ; CRH ; corticotropin-releasing hormone ; CRHBP ; CRH binding protein ; CRHR1 ; type I CRH receptor ; ERK ; extracellular signal-regulated kinase ; FKBP5 ; FK506-binding protein 51 ; GRADE ; grading of recommendations ; assessment ; development and evaluation ; HPA axis ; hypothalamus&ndash ; pituitary&ndash ; adrenal axis ; HIV ; human immunodeficiency virus ; HSP-90 ; heat shock protein 90 ; MAPK ; mitogen-activated protein kinases ; NOS ; Newcastle-
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：46-61
- 全文大小：1859 K
文摘
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Suicide is a serious public health problem worldwide with an estimated annual mortality rate of 14.5 deaths per 100,000 people.
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FKBP5 and CRHR1 genes have been associated importantly with epigenetic alterations in molecular pathways of the function HPA axis and serotonergic system in patients with suicidal behavior.
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An understanding of the functional consequence of FKBP5 and CRHR1 genes and its polymorphisms from a neuropathological perspective would be convenient to advance our understanding of their role in the HPA axis alterations with suicidal behavior.