Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular carcinoma SMMC-7721 cells
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- 作者：Xiaoqin Wu ; Bin Zhao ; Yahui Cheng ; Yang Yang ; Cheng Huang ; Xiaoming Meng ; Baoming Wu ; Lei Zhang ; Xiongwen Lv ; Jun Li ; xqwu01@foxmail.com" class="auth_mail" title="E-mail the corresponding author ; lj@ahmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCC ; Hepatocellular carcinoma ; MBDs ; Methyl-CpG-binding proteins ; MeCP2 ; Methyl-CpG binding protein 2 ; Shh ; Sonic hedgehog ; HDAC2 ; Histone deacetylase 2 ; CDK4 ; Cyclin-dependent kinase 4 ; 5-azadC ; 5-Aza-2&prime ; -deoxycytidine ; PTCH-1 ; Patched-1 ; SMO ; Smoothened ; CSCs ; Cancer stem cells ; RT ; Radiotherapy
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：1 October 2015
- 年：2015
- 卷：288
- 期：1
- 页码：74-83
- 全文大小：1608 K
文摘
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MeCP2 plays a key role in the proliferation of human HCC cells.
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Melittin reduces MeCP2 expression in vitro.
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Melittin induces G0/G1 cell cycle arrest in SMMC-7721 cells.
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MeCP2 modulates the Shh signaling pathway in SMMC-7721 cells.
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Melittin blocks the Shh signaling pathway in SMMC-7721 cells.