Proteomic profiling of hyperplasia/atypia and adenoma-induced by NNK in mouse lung identified multiple proteins as potential biomarkers for early detection
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- 作者：Arunangshu Dasa ; aud12@psu.edu" class="auth_mail" title="E-mail the corresponding author ; James D. Bortner Jr.a ; 1 ; Cesar Aliagaa ; Timothy Cooperb ; Anne Stanleyc ; Bruce A. Stanleyc ; Chandra P. Belanid ; Karam El-Bayoumya ; kee2@psu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：NNK4 ; -(methylnitrosamino)-1-(3-pyridyl)-1-butanone ; p-XSC ; 1 ; 4-phenylenebis(methylene)selenocyanate ; iTRAQ ; isobaric tags for relative and absolute quantitation ; SCLC ; small cell lung cancer ; NSCLC ; non-small cell lung cancer ; MS ; mass spectrometry ; IARC ; International Agency for Research on Cancer ; ABI ; Applied Biologicals Inc ; TEAB ; triethylammoniumbicarbonate ; TCEP ; tris-(2-carboxyethyl) phosphine ; LC ; liquid chromatography ; SCX ; strong cation exchange ; MALDI ; matrix assisted laser desorptio
- 刊名：EuPA Open Proteomics
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：9
- 期：Complete
- 页码：23-33
- 全文大小：1851 K
文摘
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Multiple proteins were modulated during early stages of lung tumorigenesis.
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Cbr2, Anx A, Selenbp1, Hmgb1, Hsp90b1 were modified during hyperplasia/atypia/adenoma.
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These proteins are potential biomarkers for early stages of lung tumorigenesis.