Bone marrow fibrosis with fibrocytic and immunoregulatory responses induced by β-catenin activation in osteoprogenitors
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- 作者：Jian Yu ; Jingjing Cao ; Hanjun Li ; Pei Liu ; Shuqin Xu ; Rujiang Zhou ; Zhengju Yao ; zjyao@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xizhi Guo ; xzguo2005@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Wnt/β-catenin signaling ; Bone marrow ; Fibrosis ; TGFβ1 ; Immunoregulatory responses
- 刊名：Bone
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：38-46
- 全文大小：2648 K
文摘
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Col1a1-Cre (3.6-kb) activity covers osteoblasts and fibrocytes in bone marrow.
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Constitutive activation of β-catenin by Col1a1-Cre (3.6-kb) results in fibrosis.
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Fibrocytes are expanded in bone marrow under the stimulation of β-catenin.
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Immunoregulatory responses accompany the fibrotic process in bone marrow.