Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis
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- 作者：Satomi Hisamotoa ; hisamoto@intmed1.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Shinji Shimodaa ; sshimoda@intmed1.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kenichi Haradab ; kenichih@med.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Sho Iwasakaa ; make_my_own_niche@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author ; Shinya Onoharaa ; onohara.shinya.678@m.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yong Chonga ; cychong@gj9.so-net.ne.jp" class="auth_mail" title="E-mail the corresponding author ; Minoru Nakamurac ; nakamuram@nagasaki-mc.com" class="auth_mail" title="E-mail the corresponding author ; Yuki Bekkid ; y-bekki@med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Tomoharu Yoshizumid ; yosizumi@surg2.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Toru Ikegamid ; tikesurg@surg2.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yoshihiko Maeharad ; maehara@surg2.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Xiao-Song Hee ; xiaosong@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; M. Eric Gershwine ; megershwin@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author ; Koichi Akashia ; akashi@med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Autoimmune cholangitis ; Cholangiocytes ; Inflammation ; Cytokine
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：150-160
- 全文大小：1671 K
文摘
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Hydrophobic bile acids reduce AE2 expression in BEC through induction of ROS.
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Reduced AE2 enhances the production of cytokines and chemokines like as SASP.
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The change was recovered by inhibition of ROS.
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PBC patients have increased ROS and reduced AE2 in BEC.