The Yeast Cyclin-Dependent Kinase Routes Carbon Fluxes to Fuel Cell Cycle Progression
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- 作者：Jennifer C. Ewald1 ; Andreas Kuehne2 ; 3 ; Nicola Zamboni2 ; Jan M. Skotheim1 ; skotheim@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：19 May 2016
- 年：2016
- 卷：62
- 期：4
- 页码：532-545
- 全文大小：4071 K
文摘
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Cell cycle progression triggers global changes in metabolism
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The cell cycle kinase Cdk1 activates the trehalase Nth1 at the G1/S transition
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Active Nth1 releases trehalose to fuel biosynthesis during S/G2/M
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Trehalose utilization enables cell cycle progression even during acute starvation