Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection
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- 作者：Daniel Fernandez-Ruiz1 ; Wei Yi Ng1 ; 2 ; Lauren E. Holz1 ; 4 ; Joel Z. Ma1 ; Ali Zaid1 ; 4 ; Yik Chun Wong6 ; Lei Shong Lau1 ; Vanessa Mollard3 ; Anton Cozijnsen3 ; Nicholas Collins1 ; Jessica Li1 ; 2 ; Gayle M. Davey1 ; 4 ; Yu Kato1 ; Sapna Devi1 ; 4 ; Roghieh Skandari5 ; Michael Pauley5 ; Jonathan H. Manton5 ; Dale I. Godfrey1 ; 4 ; Asolina Braun1 ; Szun Szun Tay6 ; Peck Szee Tan2 ; 8 ; David G. Bowen6 ; Friedrich Koch-Nolte7 ; Bjö ; rn Rissiek7 ; Francis R. Carbone1 ; Brendan S. Crabb2 ; Mireille Lahoud2 ; 8 ; Ian A. Cockburn9 ; Scott N. Mueller1 ; 4 ; Patrick Bertolino6 ; Geoffrey I. McFadden3 ; Irina Caminschi2 ; 8 ; 10 ; irina.caminschi@monash.edu.au" class="auth_mail" title="E-mail the corresponding author ; William R. Heath1 ; 4 ; 10 ; wrheath@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：tissue-resident memory ; memory T cells ; liver ; malaria ; sporozoite ; CD8+ T cells ; vaccine ; Clec9A ; liver surveillance
- 刊名：Immunity
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：45
- 期：4
- 页码：889-902
- 全文大小：4137 K
文摘
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CD8+ tissue-resident memory T cells (Trm cells) can be found in the murine liver
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These liver Trm cells survey the liver from within the sinusoids
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A prime-and-trap vaccination strategy efficiently induces liver Trm cells
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Liver Trm cells are essential for protection against liver-stage malaria after vaccination