A probabilistic approach for the interpretation of RNA profiles as cell type evidence
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- 作者：Jacob de Zoetea ; j.c.dezoete@uva.nl" class="auth_mail" title="E-mail the corresponding author ; James Curranb ; j.curran@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Marjan Sjerpsc ; m.sjerps@nfi.minvenj.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：RNA profiles ; Probabilistic approach ; Naï ; ve Bayes ; Multinomial logistic regression ; Cell type ; Body fluid
- 刊名：Forensic Science International: Genetics
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：20
- 期：Complete
- 页码：30-44
- 全文大小：1220 K
文摘
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Existing methods for the interpretation of RNA profiles are discussed.
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Two new probabilistic methods are introduced.
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The limitations and opportunities of these methods are discussed.
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The performance of all methods are compared on two datasets using several criteria.
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Probabilistic methods perform better and have come with multiple other benefits.