Calcineurin and mTOR inhibitors have opposing effects on regulatory T cells while reducing regulatory B cell populations in kidney transplant recipients
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- 作者：Irene Latorrea ; 1 ; irelatorre@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ana Esteve-Solea ; 2 ; 3 ; a.estevesole@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Dolores Redondob ; 3 ; doloredondop@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sandra Giesta ; sandragiest-research@yahoo.de" class="auth_mail" title="E-mail the corresponding author ; Jordi Argilagueta ; jordi.argilaguet@upf.edu" class="auth_mail" title="E-mail the corresponding author ; Sara Alvarezb ; saraalvarez.mo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Cristina Peligeroa ; cristina.peligero@upf.edu" class="auth_mail" title="E-mail the corresponding author ; Isabelle Forstmanna ; isabellef@web.de" class="auth_mail" title="E-mail the corresponding author ; Marta Crespob ; MCrespo@parcdesalutmar.cat" class="auth_mail" title="E-mail the corresponding author ; Julio Pascualb ; jpascualsantos@parcdesalutmar.cat" class="auth_mail" title="E-mail the corresponding author ; Andreas Meyerhansa ; c ; andreas.meyerhans@upf.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BFA ; brefeldin A ; Breg cells ; regulatory B cells ; B10 ; IL10-secreting B cells ; CNI ; calcineurin inhibitors ; eGFR ; estimated glomerular filtration rate ; KT ; kidney transplant ; LPS ; lipopolysaccharide ; mTOR ; mammalian target of rapamycin ; PBMCs ; peripheral blood mononuclear cells ; Treg cells ; regulatory T cells
- 刊名：Transplant Immunology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：1-6
- 全文大小：615 K
文摘
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Regulatory B cells increase over time after transplantation, suggesting that they might be related with graft survival.
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Immunosuppressive drugs have a differential effect on regulatory lymphocyte subsets.
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KT recipients under CNI treatment show reduced levels of regulatory B and T cells.
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KT recipients under mTOR treatment show reduced levels of regulatory B cells while regulatory T cells numbers are maintained.