Chemical characterization and in vitro antitumor activity of a single-component polysaccharide from Taxus chinensis var. mairei
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- 作者：Mianbin Wua ; c ; 1 ; wumb@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Feifei Zhanga ; 1 ; 21228180@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhangping Yub ; yuzp@163.com" class="auth_mail" title="E-mail the corresponding author ; Jianping Lina ; linjp@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Lirong Yanga ; lryang@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Taxus chinensis var. mairei ; Polysaccharide ; Isolation ; Purification ; Characteristic ; Antitumor
- 刊名：Carbohydrate Polymers
- 出版年：2015
- 出版时间：20 November 2015
- 年：2015
- 卷：133
- 期：Complete
- 页码：294-301
- 全文大小：1186 K
文摘
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This work is the first time reported in research of structure and bioactivity of an alkali-soluble single-component polysaccharide (named CPTC-2) isolated and purified from Taxus chinensis var. mairei by ion-exchange and gel-permeation chromatography in series.
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The authors used a variety of methods to analyze the structure properties of polysaccharide and get a fully understanding of the structure of CPTC-2. Moreover, the combination of MTS assay and flow cytometry method was adopted to study the antitumor function of CPTC-2.
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Finally, the partial relationship between structure of the polysaccharide and its antitumor activity was obtained.