Fibroblast spheroids as a model to study sustained fibroblast quiescence and their crosstalk with tumor cells
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- 作者：Pertteli Salmenperä ; a ; 1 ; pertteli.salmenpera@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Piia-Riitta Karhemob ; 1 ; Kati Rä ; sä ; nena ; Pirjo Laakkonenb ; 1 ; Antti Vaheria ; 1
- 关键词：Fibroblast activation ; Nemosis ; Secretory phenotype ; Cellular senescence ; quiescence
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：345
- 期：1
- 页码：17-24
- 全文大小：9284 K
文摘
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Fibroblasts acquire a sustained quiescence when grown as multicellular spheroids.
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This quiescence is associated with drastic change in gene expression.
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Fibroblasts spheroids secrete various inflammation-linked cytokines and chemokines.
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Fibroblasts spheroids reduced growth of RT3 SCC cells in xenograft model.