Nucleus and nucleus-cytoskeleton connections in 3D cell migration
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- 作者：Lingling Liu liulingling2012@163.com" class="auth_mail" title="E-mail the corresponding author ; Qing Luo qing.luo@cqu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jinghui Sun sunjhemail@163.com" class="auth_mail" title="E-mail the corresponding author ; Guanbin Song ; song@cqu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：2D ; Two dimension ; 3D ; Three dimension ; ECM ; Extracellular matrix ; GCL ; Germ cell-less ; HDAC ; Histone deacetylase ; HMT ; Histone methyltransferases ; HP 1 ; Heterochromatin protein 1 ; INM ; Inner nuclear membrane ; LAP2β ; Lamina-associated polypeptide-2β ; LBR ; Lamin B receptor ; LINC ; Linker of nucleoskeleton and cytoskeleton ; NE ; Nuclear envelope ; Nesprins ; Nuclear envelope spectrin repeat proteins ; NPCs ; Nuclear pore complexes ; ONM ; Outer nuclear membrane ; SUN ; Sad1p ; UNC-84 ; TAN ; Transmembrane acti
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：348
- 期：1
- 页码：56-65
- 全文大小：2177 K
文摘
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The influence of nuclear size and stiffness in cell migration is discussed.
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We describe molecular components that govern the mechanical properties of the nucleus.
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We discuss the roles of chromatin, lamin A/C in nuclear mechanical properties and cell migration.
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We review how nuclear dynamics are connected to cytoskeleton.
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We discuss the role of nucleo-cytoskeletal coupling in cell migration.