Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency
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- 作者：Alvaro Muñ ; oz-Ló ; pez1 ; 2 ; 16 ; Damià ; Romero-Moya1 ; 2 ; 16 ; Cristina Prieto1 ; 2 ; Veró ; nica Ramos-Mejí ; a3 ; Antonio Agraz-Doblas1 ; 2 ; 4 ; Ignacio Varela4 ; Marcus Buschbeck1 ; Anna Palau1 ; Xonia Carvajal-Vergara5 ; Alessandra Giorgetti1 ; Anthony Ford6 ; Majlinda Lako7 ; Isabel Granada1 ; 8 ; Neus Ruiz-Xivillé ; 1 ; 8 ; Sandra Rodrí ; guez-Perales9 ; Raul Torres-Ruí ; z1 ; 9 ; Ronald W. Stam10 ; Jose Luis Fuster11 ; Mario F. Fraga12 ; Mahito Nakanishi13 ; Gianni Cazzaniga14 ; Michela Bardini14 ; Isabel Cobo1 ; 12 ; Gustavo F. Bayon12 ; Agustin F. Fernandez12 ; Clara Bueno1 ; 2 ; cbueno@carrerasresearch.org" class="auth_mail" title="E-mail the corresponding author ; Pablo Menendez1 ; 2 ; 15 ; pmenendez@carrerasresearch.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：iPSC ; cancer reprogramming ; MLL-AF4 ; B-ALL ; Sendai virus ; transcriptome ; DNA methylome
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：7
- 期：4
- 页码：602-618
- 全文大小：3613 K
文摘
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Neither primary B-ALL blasts nor leukemic B cell lines can be reprogrammed to iPSCs
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Global transcriptome and DNA methylome suggest a developmental refractoriness