Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats
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- 作者：Rafael M. Bitencourta ; 1 ; Ana C. Guerra de Souzaa ; 1 ; Maí ; ra A. Biccaa ; 1 ; Fabrí ; cio A. Pamplonaa ; b ; Nelson de Melloa ; Giselle F. Passosa ; c ; Rodrigo Medeirosa ; Reinaldo N. Takahashia ; Joã ; o B. Calixtoa ; Rui D. Prediger ; PhDa ; ruidsp@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bradykinin ; B1 receptor ; Middle age ; Hippocampus ; Alzheimer&rsquo ; s disease ; Cortex ; Learning and memory ; Rat
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：74-81
- 全文大小：2139 K
文摘
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Increased B1R expression in the hippocampus and cerebral cortex of middle-aged rats.
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Hippocampal B1R antagonism improves the spatial learning and memory deficits of middle-aged rats.
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Hippocampal B2R antagonism failed to reverse the cognitive deficits of middle-aged rats.