Enhanced growth inhibition of prostate cancer in vitro and in vivo by a recombinant adenovirus-mediated dual-aptamer modified drug delivery system
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- 作者：Pei Jinga ; b ; 1 ; Shousong Caoc ; 1 ; Shuangli Xiaoa ; 1 ; Xiaoqin Zhanga ; Siyun Ked ; Famin Kea ; Xin Yua ; Li Wange ; Shurong Wanga ; Yuling Luoa ; Zhirong Zhonga ; zhongzhirong@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dual aptamer ; Recombinant adenovirus ; Doxorubicin ; Targeted drug delivery system ; Antitumor activity and toxicity
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 December 2016
- 年：2016
- 卷：383
- 期：2
- 页码：230-242
- 全文大小：2983 K
文摘
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Successfully established a dual aptamer modified tumor targeting gene and DOX delivery system mediated by recombinant adenovirus.
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The uptake of ADDP-Ad5 and expression of reporter gene are enhanced by the system in LNCaP and PC3 cells.
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ADDP-Ad5 significantly inhibits the cell growth of LNCaP and PC3 cells but not WPMY-1 cells.
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ADDP-Ad5 is active in vivo against LNCaP and PC3 tumor xenografts and has no or slight toxicity to the mice.