Is metal contamination responsible for increasing aneuploidy levels in the Manila clam Ruditapes philippinarum?
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Metal effects on Ruditapes philippinarum were assessed using aneuploidy as cytogenetic endpoint.

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Clam aneuploidy was generally related to sediment contamination but not to metal bioaccumulation.

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Chronic metal contamination may be inducing long-term clam aneuploidy levels.

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Vertical transmission hypothesis is suggested for the high aneuploidy levels under chronic contamination.

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Aneuploidy represents an effective tool to detect long-term metal effects on estuarine bivalves.

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