Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis
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- 作者：Shyi-Jou Chena ; b ; c ; Shing-Hwa Huangd ; e ; Jing-Wun Chenf ; Kai-Chen Wangg ; h ; Yung-Rong Yangc ; Pi-Fang Liui ; Gu-Jiun Line ; lingujiun@mail.ndmctsgh.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Huey-Kang Sytwua ; c ; f
- 关键词：Melatonin ; multiple sclerosis ; Experimental autoimmune encephalomyelitis ; Autoimmune disease ; Interleukin-10 ; Interleukin-27 ; Th17 ; Chemokine
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：169-177
- 全文大小：1284 K
文摘
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We report a therapeutic effect of melatonin in experimental autoimmune encephalomyelitis.
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Melatonin treatment reduces the expression of IL-17 and the infiltration of Th17 cells in central nervous system.
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Melatonin upregulates the expression of IL-10 via enhances the secretion of IL-27 in dendritic cells in the spleen.
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The expressions of inflammatory chemokines and IL-6 in the spinal cord are reduced under melatonin treatment.