Role of testosterone in regulating induction of TNF-α in rat spleen via ERK signaling pathway
详细信息 查看全文
- 作者：Chien-Wei Chena ; Cai-Yun Jiana ; Po-Han Lina ; Chih-Chieh Chena ; Fu-Kong Lieub ; Christina Soongb ; Chu-Chun Hsieha ; Chi-Yun Wana ; Galina Idovai ; Sindy Hug ; h ; Shyi-Wu Wangc ; g ; 1 ; swwang@mail.cgu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Paulus S. Wanga ; d ; e ; f ; 1 ; pswang@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Testosterone ; Orchidectomy ; Splenocyte ; Inflammation ; TNF-α
- 刊名：Steroids
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：148-154
- 全文大小：1024 K
文摘
- class="listitem" id="list_l0005">
- class="label">•
Testosterone withdrawal is associated with strong inflammation.
- class="label">•
Orchidectomy triggers NO production and LPS-evoked TNF-α secretion ex vivo.
- class="label">•
p-ERK protein expression was markedly enhanced on orchidectomized rats.
- class="label">•
Orchidectomy resulted in splenomegaly and promoted splenocyte proliferation rate.
- class="label">•
Testosterone attenuated inflammatory molecules secretion in vitro.