Innate and adaptive cellular phenotypes contributing to pulmonary disease in mice after respiratory syncytial virus immunization and infection
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- 作者：Young-Tae Leea ; Ki-Hye Kima ; Hye Suk Hwanga ; b ; Youri Leea ; b ; Young-Man Kwona ; Eun-Ju Koa ; b ; Yu-Jin Junga ; b ; Yu-Na Leea ; Min-Chul Kima ; c ; Sang-Moo Kanga ; b ; skang24@gsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Respiratory syncytial virus (RSV) ; Alveolar macrophages ; Formalin-inactivated RSV ; Vaccine ; Clodronate liposome
- 刊名：Virology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：485
- 期：Complete
- 页码：36-46
- 全文大小：1806 K
文摘
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FI-RSV immunization induced infiltration of eosinophils and neutrophils in the lungs.
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Subsets of dendritic cells were found to contribute to RSV vaccine-enhanced disease.
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RSV G specific IL-4+ CD4+ T cells were found to be an important factor in disease.
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Alveolar macrophages differentially modulated inflammation and protection.