Combined virus-like particle and fusion protein-encoding DNA vaccination of cotton rats induces protection against respiratory syncytial virus without causing vaccine-enhanced disease
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- 作者：Hye Suk Hwanga ; Young-Tae Leea ; Ki-Hye Kima ; Soojin Parka ; Young-Man Kwona ; Youri Leea ; Eun-Ju Koa ; Yu-Jin Junga ; Jong Seok Leea ; b ; Yu-Jin Kima ; Yu-Na Leea ; c ; Min-Chul Kima ; c ; Minkyoung Choa ; Sang-Moo Kanga ; skang24@gsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Respiratory syncytial virus ; Safety ; Cotton rats ; Virus-like particle ; Protection
- 刊名：Virology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：494
- 期：Complete
- 页码：215-224
- 全文大小：3796 K
文摘
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Combined RSV FFG VLP vaccine is effective in inducing F specific responses.
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FFG VLP vaccine confers RSV neutralizing activity and viral control in cotton rats.
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Cotton rats with RSV FFG VLP vaccination do not show vaccine-enhanced disease.
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Cotton rats with FFG VLP vaccine induce F specific antibody secreting cell responses.
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Cotton rats with FFG VLP do not induce lung cellular infiltrates and Th2 cytokine.