MiR-367 negatively regulates apoptosis induced by adriamycin in osteosarcoma cells by targeting KLF4
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- 作者：Guang-Chao Wang1 ; Qian-Yun He1 ; Da-Ke Tong ; Chuan-Feng Wang ; Kang Liu ; Chen Ding ; Fang Ji ; fangjismmu@126.com" class="auth_mail" title="E-mail the corresponding author ; Hao Zhang ; zhanghsmmu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MiR-367 ; Osteosarcoma ; Adriamycin ; KLF4 ; Apoptosis ; Chemotherapy resistance
- 刊名：Journal of Bone Oncology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：5
- 期：2
- 页码：51-56
- 全文大小：2086 K
文摘
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miR-367 functions as an oncogene in OS targeting the tumor suppressor KLF4.
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ADR induces apoptosis in OS via miR-367/KLF4/Bax signaling pathway.
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miR-367 enhances the resistance of ADR to OS cells through suppressing KLF4.
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miR-367 could be a potential biomarker of chemotherapy resistance against OS.