Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies
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- 作者：Philip C. Weisshuhn1 ; Devon Sheppard2 ; Paul Taylor1 ; Pat Whiteman1 ; Susan M. Lea2 ; Penny A. Handford1 ; penny.handford@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Christina Redfield1 ; christina.redfield@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：24
- 期：4
- 页码：555-566
- 全文大小：2473 K
文摘
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The EGF4-13 region of human Notch1 contains both bent and flexible interfaces
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This changes the classical view of the receptor as a rigid linear structure
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Extra interaction sites of Notch with ligand may occur along its longitudinal axis
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Interfaces next to ligand-binding site differentially modulate ligand interactions