Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress
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- 作者：Sylvia Hillera ; Robert DeKroonb ; Eric D. Hamlettc ; Longquan Xua ; Cristina Osoriod ; Jennifer Robinettec ; d ; Witold Winnike ; Stephen Simingtonb ; Nobuyo Maedaa ; Oscar Alzatef ; alzate@medicine.tamhsc.edu" class="auth_mail" title="E-mail the corresponding author ; Xianwen Yia ; xyi2000@med.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-Lipoic acid ; Antioxidant ; Nitric oxide (NO) ; Nitrosative stress (NS) ; Reactive oxygen species (ROS) ; Mitochondria ; S-nitrosylation ; ATP
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1860
- 期：1
- 页码：36-45
- 全文大小：1395 K
文摘
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We identified new antioxidant protein targets for α-lipoic acid activity.
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α-Lipoic acid supplementation restores mitochondrial enzymatic activities.
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α-Lipoic acid improves ATP generation inhibited by nitrosative stress.
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Our findings disclose a novel redox regulatory function of α-lipoic acid.
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Our data suggest a novel strategy for treatment of inflammation-related diseases.