DTI-based connectome analysis of adolescents with major depressive disorder reveals hypoconnectivity of the right caudate
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- 作者：Olga Tymofiyevaa ; Olga.Tymofiyeva@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Colm G. Connollyb ; Tiffany C. Hob ; c ; Matthew D. Sacchetb ; c ; Eva Henje Blomb ; d ; Kaja Z. LeWinnb ; Duan Xua ; Tony T. Yangb
- 关键词：MRI ; Adolescence ; Brain ; Depression ; Diffusion ; Tractography ; Connectomics ; Graph theory ; Neural network ; Caudate
- 刊名：Journal of Affective Disorders
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：207
- 期：Complete
- 页码：18-25
- 全文大小：1952 K
文摘
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FA-weighted node strength of the right caudate was lower in depressed adolescents.
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FA-weighted node strength of the right caudate correlated positively with age.
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A cluster centered on the right caudate was hypoconnected in depressed subjects.
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R. caudate - middle frontal gyrus connection anticorrelated with stress in MDD.
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We proposed two models of dysfunctional processes underlying adolescent depression.