Applying juvenile SIS increased susceptibility to PTZ-induced seizure.
NMDA receptor antagonists reversed the proconvulsant effect of SIS.
NOS inhibitors potentiated the anticonvulsant effects of NMDA receptor antagonists.
SIS upregulated NR2B subunit of NMDA receptor in the hippocampus.
Dysregulation of hippocampal NMDA/NO pathway is involved in proconvulsant effects of SIS.