NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice
详细信息 查看全文
- 作者：Shayan Amiria ; b ; 1 ; From.here.till.there@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Arya Haj-Mirzaiana ; b ; 1 ; Arya.mirzaian@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hossein Amini-khoeia ; b ; aminikhoyi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Majid Momenyc ; Majid.momeny@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Armin Shirzadiana ; b ; armin_shirzadian@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Maryam Rahimi Balaeid ; Maryam_rahimib@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Ghazaleh Zarrinradc ; Gh.rad87@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mahmoud Ghazi-Khansaria ; b ; ghazikha@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Romina Azizia ; ejtemam@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Ahmad Reza Dehpoura ; b ; dehpour@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Shahram Ejtemaei Mehra ; b ; ejtemam@gmail.com" class="auth_mail" title="E-mail the corresponding author ; ejtemam@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Juvenile social isolation stress ; NMDA receptor ; Nitric oxide ; PTZ-induced seizures ; NR2B subunit
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：158-168
- 全文大小：1629 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
Applying juvenile SIS increased susceptibility to PTZ-induced seizure.
- class="label">•
NMDA receptor antagonists reversed the proconvulsant effect of SIS.
- class="label">•
NOS inhibitors potentiated the anticonvulsant effects of NMDA receptor antagonists.
- class="label">•
SIS upregulated NR2B subunit of NMDA receptor in the hippocampus.
- class="label">•
Dysregulation of hippocampal NMDA/NO pathway is involved in proconvulsant effects of SIS.