Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion
详细信息 查看全文
- 作者：Sandra Capellera-Garcia1 ; Julian Pulecio2 ; Kishori Dhulipala1 ; Kavitha Siva1 ; Violeta Rayon-Estrada3 ; Sofie Singbrant1 ; Mikael N.E. Sommarin4 ; Carl R. Walkley5 ; Shamit Soneji4 ; Gö ; ran Karlsson4 ; Á ; ngel Raya2 ; 6 ; 7 ; Vijay G. Sankaran8 ; 9 ; Johan Flygare1 ; johan.flygare@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：15
- 期：11
- 页码：2550-2562
- 全文大小：4451 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
Gata1, Tal1, Lmo2, and c-Myc reprogram fibroblasts to erythroid progenitors (iEPs)
- class="label">•
iEP gene expression is more similar to that of primitive than definitive erythroblasts
- class="label">•
Klf1 or Myb overexpression induces adult hemoglobin expression in iEPs