This is the first description of the effects of elcatonin on unloaded animal bones.
Elcatonin prevents trabecular bone loss due to unloading in the hindlimbs.
Unloading increases expression of calcitonin receptors in bone marrow cells.
Elcatonin suppresses osteoclast development without affecting osteoblast development.
Elcatonin inhibits differentiation process from preosteoclasts to osteoclasts in vivo.