Human dorsal-root-ganglion perfusion measured in-vivo by MRI
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- 作者：Tim Godela ; Tim.godel@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Mirko Phama ; Mirko.pham@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Sabine Heilanda ; Sabine.heiland@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Martin Bendszusa ; Martin.bendszus@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Philipp Bä ; umera ; b ; P.baeumer@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：DRG ; dorsal root ganglia ; CBRA ; cell body rich area ; NFRA ; nerve fiber rich area ; PNS ; peripheral nervous system ; DCE ; dynamic-contrast-enhanced ; VIBE ; volumetric-interpolated-breathhold-examination ; ROI ; region of interest ; AIF ; arterial input function ; ESS ; extracellular extravascular space
- 刊名：NeuroImage
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：81-87
- 全文大小：1074 K
文摘
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Non-invasive and in-vivo measurement of human dorsal-root-ganglion (DRG) perfusion by MRI is a feasible technique.
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DRG shows significantly increased permeability and interstitial leakage compared to spinal nerves.
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Permeability and interstitial leakage are significantly higher in the cell-body-rich-area than in the nerve-fiber-rich-area.
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Female gender is associated with a significantly increased vascular permeability within the DRG compared to male.
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This technique may become useful for future research on poorly understood human sensory neuropathies and pain syndromes.