Four new cytochalasins were isolated from mangrove fungal endophytes, Phomopsis spp. xy21 and xy22.
Phomopsichalasins D and E represent the first two 10-phenyl[11]-cytochalasans containing a 12-carboxyl function.
Phomopsichalasin G exhibited potent inhibitory activities against HCT-8, HCT-8/T, A549, MDA-MB-231, and A2780 cancer cell lines.